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KMID : 1161920220190030130
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Journal of Medicine and Life Science
2022 Volume.19 No. 3 p.130 ~ p.133
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Neuromyelitis optica spectrum disorders with an inverted V sign on spinal cord magnetic resonance imaging: antiaquaporin-4 antibody and functional vitamin B12 deficiency
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Bang Sung-Jo
Kim So-Hyeon
Jeong Yeong-Seok
Lee Seo-Hyeon
Seok Hung-Youl
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Abstract
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Several studies have reported a possible link between antiaquaporin- 4 antibody and vitamin B12 deficiency in neuromyelitis optica spectrum disorder (NMOSD). Bilaterally symmetric hyperintense signals on magnetic resonance imaging (MRI) of the posterior columns, called the inverted V sign, are a characteristic feature of subacute combined degeneration associated with vitamin B12 deficiency. We report a patient with anti-aquaporin-4 antibodypositive NMOSD and an inverted V sign on MRI of the spinal cord and address the association between anti-aquaporin-4 antibody and functional vitamin B12 deficiency.
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KEYWORD
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Neuromyelitis Optica, Vitamin B12, Aquaporin 4
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